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NCBI Variation Services API boundary

Official-source access, authentication, request-shaping, freshness, legal, and interpretation boundaries for NCBI Variation Services API.

version 1.0.0freshness currentobserved 2026-08-28T15:06:26Z

resource.public-data.ncbi-variation-api
sha256:4f5ad5d172ad1f38b37332a29ff716a40670526a89201039abce5080320163d0

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Evidence-backed facts

  1. NCBI Variation Services expose variant normalization, representation translation, SPDI, HGVS-related transformations, reference sequences, placements, and associated public variation data. informative
  2. Public reads require no user credential and do not grant ClinVar submission, curation, reference-sequence mutation, diagnostic, or regulatory authority. informative
  3. Clients must bind assembly or reference accession, sequence position, deleted and inserted sequence, notation, endpoint, and response representation and handle ambiguous or failed normalization. informative
  4. Normalized representation is not evidence of variant presence, zygosity, pathogenicity, phenotype, sample identity, clinical significance, or consistency across genome assemblies. informative