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PubChem PUG REST API boundary

Official-source access, authentication, request-shaping, paging, freshness, legal, and interpretation boundaries for PubChem PUG REST API.

version 1.0.0freshness currentobserved 2026-08-28T05:32:38Z

resource.public-data.pubchem-pug-rest-api
sha256:1824da14e0b012dbce7115726716ee9c9f36d84bc872a8af90fe5dc2357d9329

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Evidence-backed facts

  1. PubChem PUG REST exposes compounds, substances, assays, genes, proteins, pathways, taxonomies, cells, properties, identifiers, and related operations through a URL-based API. informative
  2. The shared public service offers no API keys or whitelisting for higher volume, and public retrieval grants no record-deposit, curation, clinical, or regulatory authority. informative
  3. Clients must bind input domain and identifier, operation, output format, options, list-key paging, and correct POST content type and remain at or below five requests per second. informative
  4. PubChem records aggregate submitted and computed chemical information that can change or conflict and do not prove compound identity in a specimen, safety, efficacy, legal status, or medical suitability. informative

Primary sources

PubChem PUG REST

U.S. National Library of Medicine · observed 2026-08-28T05:32:38Z